Priyanka Gandhi Vadra filed her nomination for the Wayanad Lok Sabha by-election, marking her first personal electoral campaign after 35 years of campaigning for others. Speaking at a public meeting in Wayanad, she expressed her unique experience, stating, "This is the first time I am campaigning in an election and seeking your support for myself." Priyanka highlighted her history of campaigning since age 17 for her father, former Prime Minister Rajiv Gandhi, and her mother and brother. She thanked Congress president Mallikarjun Kharge for the opportunity to contest and emphasized her desire to represent the constituency, previously held by her brother Rahul Gandhi, who has vacated the seat.

The NHS in England has rejected the use of donanemab, a new Alzheimer's drug, despite the UK’s medicines regulator indicating it could be licensed. The National Institute of Health and Care Excellence (NICE) determined that donanemab "does not currently demonstrate value for the NHS." This rejection is notable as it is the second time in a few months that NICE has turned down a new treatment for Alzheimer's. Donanemab, produced by pharmaceutical company Eli Lilly, is designed as a targeted antibody drug aimed at slowing the early stages of Alzheimer's disease, highlighting ongoing challenges in accessing effective treatments.

Tensions have escalated in Bangladesh as hundreds of protesters stormed the President's residence, Bangabhaban, in Dhaka on Tuesday night. The protesters are demanding the resignation of President Mohammed Shahabuddin, claiming he "lied" about the resignation of former Prime Minister Sheikh Hasina in August. This unrest follows a political crisis that resulted in the end of Hasina's 16-year tenure and her subsequent escape to India. The protests signify growing public dissatisfaction with the current political climate and leadership. The situation remains tense as demonstrators continue to voice their demands for accountability from the government.

The Konark Temple in Odisha will be closed on October 24 and 25 as Cyclone Dana approaches the eastern coast. Six districts in West Bengal, including North and South 24 Parganas, Howrah, Hooghly, East Medinipur, and West Medinipur, are on high alert for the cyclone, which is expected to make landfall between Odisha’s Puri and West Bengal’s Ganga Sagar early on October 25. The India Meteorological Department (IMD) has warned of wind speeds at landfall reaching 100-110 km per hour, gusting up to 120 kmph. Kolkata, located about 250 km from the landfall zone, may experience wind speeds of 50 to 60 kmph.

The Supreme Court expressed strong dissatisfaction with the central and Punjab and Haryana governments regarding their failure to enforce anti-pollution measures as air quality in Delhi and the national capital region remains very poor. During a hearing, the bench, comprising Justices Abhay S Oka, A Amanullah, and AG Masih, labeled the states' efforts to address farm fires as "mere eyewash." The court highlighted the lack of prosecution and financial penalties against farmers violating pollution laws and suggested that Haryana's inaction could be a policy favoring certain farmers. This ongoing non-compliance raises concerns about increasing respiratory health risks in the region.

An under-construction building in Bengaluru collapsed on Tuesday evening amid heavy rain, resulting in six deaths. Thirteen people were rescued, while officials fear some may still be trapped under the debris. Rescue operations are ongoing. The police have arrested the building owner, Muniraju Reddy, and charged him with negligence. The collapse has raised concerns over safety standards in construction projects during adverse weather. Authorities are continuing efforts to locate and rescue any remaining survivors as an investigation into the incident progresses. The case underscores the need for stricter regulations in construction safety.

Police have stated that the shooters who killed NCP leader Baba Siddique were in contact with Anmol Bishnoi, brother of gangster Lawrence Bishnoi, prior to the attack. Anmol, who was communicating from the US and Canada, shared Zeeshan Siddique’s image with the shooters via Snapchat. The accused used multiple Snapchat accounts to stay connected with Anmol. Baba Siddique was shot dead outside his son Zeeshan's office during Dussehra celebrations. The motive behind the killing is still unknown, and police have recovered four mobile phones from the accused as part of the ongoing investigation.

The UK government has released 1,000 more prisoners early as part of its efforts to address chronic jail overcrowding. This follows the earlier release of 1,700 prisoners. Justice Secretary Shabana Mahmood confirmed measures are in place to prevent past errors, which led to 37 ineligible prisoners being freed. A sentencing review is underway, exploring alternatives to incarceration, including "nudge" technology and home detention curfews. Eligible non-violent offenders serving 40% of their sentence may be released, down from 50%. The move aims to prioritize prison space for high-risk offenders and alleviate pressure on the overcrowded prison system.

The Bombay High Court has suspended gangster Chhota Rajan's life sentence in the 2001 murder case of hotelier Jaya Shetty and granted him bail. The court ordered Rajan to provide a bond of ₹1 lakh. Despite being granted bail in this case, Rajan will remain in custody due to other criminal cases against him. The decision was made by a division bench of Justices Revati Mohite Dere and Prithviraj Chavan. Rajan's release from the murder case marks an important legal development, but his ongoing legal troubles will keep him in jail for the time being.

Congress general secretary Priyanka Gandhi has officially announced her candidacy for the Lok Sabha by-election in Wayanad, Kerala, by signing her nomination papers on Wednesday. The by-election became necessary after her brother, Rahul Gandhi, decided to vacate the Wayanad seat, which he had previously won along with the Raebareli constituency. Priyanka Gandhi will participate in a roadshow with Rahul Gandhi before filing her nomination. This election marks Priyanka's first entry into the electoral arena, and her candidacy is crucial for Congress as it aims to retain the Wayanad seat in the upcoming polls.